FIEBRE study – Febrile Illness Evaluation in a Broad Range of Endemicities
Project period: March 2017 – March 2021
Co-principal investigators: Katharina Kranzer and Rashida Ferrand
Funder: UKAid from the Department for International Development
FIEBRE is a multi-disciplinary project, led by the London School of Hygiene & Tropical Medicine, that is investigating the leading causes of fever in children and adults attending primary care health services and those admitted to district hospitals in Laos, Malawi, Mozambique, Myanmar and Zimbabwe. This is the largest study of its kind, aiming to tackle antimicrobial resistance and develop a ‘blueprint’ for treatment.
By identifying the treatable and preventable causes of febrile illness in the five countries, and how patients with fever are cared for, the researchers aim to design new evidence-based guidelines for the management of fever. This will ensure patients receive drugs that give them the best chance of recovery, as well as help stop the spread of antimicrobial resistance.
The BRTI is the Zimbabwe arm of this multicentre study and the team were the first site to start recruiting patients in June 2018 following successful joint training with laboratory science, clinical epidemiology and social science staff from the Malawi site.
Another part of the study will involve interviews and focus group discussions with local adults and families, prescribers, and workers who generate and implement clinical guidelines.
For more information about the study see the FIEBRE website (https://www.lshtm.ac.uk/fiebre).